Ankylosing spondylitis.

Definition of ankylosing spondylitis

Ankylosing spondylitis is a non-infectious inflammation of the spine and joints and is a member of the rheumatoid family of diseases (the umbrella term for these conditions is "spondylarthropathies").

What is ankylosing spondylitis?

Ankylosing spondylitis (formerly known as Bechterew's disease) is a chronic inflammatory, seronegative systemic disease ("spondylarthropathy") primarily affecting the axial skeleton in areas such as the spine, the sacroiliac joint, pubic symphisis, small vertebral joints and other joints. Internal organs, including the eyes, cardiovascular system, lungs and bowel may also be affected, though this does not necessarily occur. The onset of the disease occurs between the ages of 15 and 40. Its prevalence in Europe is roughly 1 %. There is a genetic predisposition (90 % of patients test positive for the hereditary factor HLA-B27).

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